As life expectancy increases further in coming decades, the goal for the future should be an increase of quality of life after menopause; thus, postmenopausal hormonal changes have become a subject of major interest in the field of women’s health. The menopausal women present a decline in circulating estrogen. Likewise, other neuroendocrine axis also decline, such as the somatotrophic axis,* Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, CMN, Instituto Mejicano del Seguro Social, México D.F. e Instituto para el Estudio de la Concepción Humana, Monterrey, NL Correspondencia: Dr. A. Zárate, Hospital de México, Agrarismo 208-601, 11800 México, D.F. e-mail: azarat. amediweb.com.mx adrenal sex steroids and prolactin; by contrast circulating insulin increases. Some alterations in calcium metabolism, immune regulation and neurotransmission are also interlinked with reduction of circulating estrogen