To explore the conditions of health and wellness in older adults beneficiaries to ISSSTE and IMSS of the Southwest Mexico City. Cross-sectional study samples of users to health services in primary care ISSSTE (n = 161) and IMSS (n = 176) in Southwest Mexico City. Were determined chronic health conditions, cognitive function, depressive symptoms, use of health services, nutritional status, functioning and disability and quality of life related to health. It is observed that there is a difference between samples ISSSTE vs. IMSS in comorbidity conditions (ISSSTE 53.4% vs. IMSS 57.9%), nutritional status (malnutrition risk ISSSTE 25.8% us. IMSS 36.4%; overweight ISSSTE 23.3% vs. IMSS 11.6%) (p < 0.05). There were no differences between samples IMSS us. ISSSTE in cognitive function, depression, use of health services, abdominal obesity, functioning and disability, and quality of life related to health. The conditions of health and wellness in older adults beneficiaries to ISSSTE and IMSS users are similar, with meaning in comorbidity conditions, nutritional status.